![]() ![]() Introduction Bacterial Secondary Infections in COVID-19: What We Know ![]() We further summarize the potential long-term consequences of SARS-CoV-2 infection. From these models, we conclude that currently available data are not sufficient to discriminate between these alternate causal pathways, and we highlight what data are required to determine the relative contribution of bacterial infection to COVID-19 morbidity and mortality. To address this question, we review current knowledge on bacterial infections in COVID-19, assess information from past viral respiratory pandemics, and simulate alternate causal models of interactions between virus, bacteria, and mortality in COVID-19. However, it is possible that the enrichment of bacterial infections in COVID-19 fatalities is simply a by-product of late-stage pathology, leading to different advice for patient management. ![]() If bacterial infections drive mortality in COVID-19, this has clear implications for patient management. The COVID-19 literature highlights that bacterial infections are more common in fatal cases than recovered cases. 4Pediatric Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children’s Healthcare of Atlanta, Atlanta, GA, United States.3Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, GA, United States.2Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA, United States.1School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, United States. ![]()
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